DRIMust - Discovering Ranked Imbalanced Motifs using suffix trees

DRIMust results for job: Sample data: PUM2 example

Calculation parameters:

Input type: Ranked list
Search mode: Single-strand
Motif length: 5-10
Statistical significance threshold: 10^-6
Total number of sequences analyzed: N=9995

DRIMust found all k-mers within requested length that are enriched at significance better than the threshold.

K-mer	P-value ≤	N	B	n	b	Enrichment
UAUAU	3.4E-254	9995	1477	993	578	3.94
UAAAU	3.8E-215	9995	1829	1001	601	3.28
UGUAUA	1.1E-209	9995	702	997	378	5.40
UGUAUAU	3.3E-206	9995	435	993	299	6.92
AUAUA	1.6E-190	9995	1280	991	481	3.79
UGUAAAU	1.9E-189	9995	474	1001	300	6.32
UGUAU	2.8E-188	9995	1707	999	553	3.24
UGUAAA	3.5E-187	9995	868	1001	398	4.58
UAUAUA	2.7E-186	9995	613	991	335	5.51
GUAUAU	2.7E-183	9995	572	993	322	5.67
GUAUA	1.8E-165	9995	1073	997	418	3.91
UGUAA	1.7E-163	9995	1699	1002	525	3.08
UAAAUA	1.6E-161	9995	748	1000	347	4.64
GUAAAU	2.9E-159	9995	652	947	315	5.10
AAAUA	4.1E-147	9995	2024	1000	553	2.73
AUAUU	2.4E-144	9995	1746	994	507	2.92
UUGUA	1.2E-138	9995	1667	1022	496	2.91
UGUAUAUA	3.2E-135	9995	229	887	173	8.51
UAUAUU	7.3E-131	9995	673	991	299	4.48
GUAUAUA	1.1E-130	9995	265	991	189	7.19
GUAAA	1.2E-128	9995	1430	1001	440	3.07
AUAUAU	9.2E-125	9995	564	991	268	4.79
UAUAA	5.2E-124	9995	1270	963	399	3.26
AUGUA	3.0E-123	9995	1512	996	445	2.95
UGUAAAUA	1.7E-121	9995	255	956	177	7.26
UAUUU	8.4E-120	9995	2333	1000	559	2.39
GUAAAUA	2.3E-113	9995	316	956	190	6.29
AAUAU	3.1E-109	9995	1580	1000	438	2.77
UAUAUAU	4.2E-105	9995	290	991	178	6.19
AUUUU	1.1E-104	9995	2760	1001	591	2.14
UUUAU	2.9E-98	9995	2108	998	497	2.36
UUAUA	1.4E-97	9995	1365	998	388	2.85
AUAUUU	1.6E-97	9995	889	1000	307	3.45
AAAUAU	4.5E-93	9995	755	1000	276	3.65
UUUGUA	2.7E-91	9995	786	1022	283	3.52
AUAAA	3.3E-91	9995	1749	1000	437	2.50
UUUUA	3.6E-86	9995	2514	1000	531	2.11
UAUUUU	5.4E-85	9995	1138	1000	334	2.93
UAAAUAU	7.1E-85	9995	308	905	160	5.74
CUGUA	1.4E-84	9995	1412	1000	377	2.67
UAAAA	1.5E-83	9995	2065	1001	469	2.27
AAUAUA	2.3E-82	9995	499	905	201	4.45
UUUAA	4.2E-82	9995	2143	1001	477	2.22
AUAUAA	4.0E-80	9995	472	968	199	4.35
AAUAA	8.8E-80	9995	1535	954	377	2.57
UUUAUA	1.5E-79	9995	688	1013	248	3.56
UAUAUUU	1.1E-78	9995	323	991	164	5.12
UAUGUA	6.8E-78	9995	510	991	207	4.09
UAUAUAA	7.6E-78	9995	228	954	135	6.20
UUGUAAA	10.0E-78	9995	311	1022	162	5.09
UUGUAA	2.2E-77	9995	597	1022	228	3.74
UUAAA	8.9E-76	9995	2046	1006	455	2.21
AUGUAU	1.1E-74	9995	540	1034	214	3.83
AUAUAUA	2.2E-73	9995	217	893	125	6.45
UUAUAU	8.5E-72	9995	542	985	206	3.86
UAAAUU	2.3E-71	9995	596	1000	218	3.66
AUGUAUA	2.9E-71	9995	234	991	133	5.73
UUUUU	3.6E-71	9995	2497	1006	505	2.01
UAAUA	2.6E-70	9995	1072	990	300	2.83
AUUUUU	3.6E-69	9995	1133	1006	311	2.73
UUGUAAAU	1.0E-68	9995	167	880	106	7.21
UUGUAUA	2.1E-67	9995	225	991	127	5.69
UAUAAA	3.5E-67	9995	562	962	202	3.73
AUAUGUA	8.1E-67	9995	218	899	120	6.12
AAAUU	2.4E-66	9995	1845	1001	410	2.22
UUGUAU	8.4E-66	9995	598	1006	212	3.52
AAUAUAU	1.4E-65	9995	221	986	124	5.69
UAUGU	1.5E-65	9995	1365	986	337	2.50
UAAAAU	1.8E-65	9995	735	994	236	3.23
ACUGUA	2.9E-65	9995	483	996	187	3.89
AAAAU	2.3E-64	9995	2276	1001	463	2.03
AUAUGU	2.3E-64	9995	468	899	174	4.13
AUAAU	3.2E-64	9995	1129	986	299	2.68
AAAUAA	1.3E-62	9995	771	953	233	3.17
UUGUAUAU	1.8E-62	9995	140	886	93	7.49
AUUAU	2.2E-62	9995	1239	981	312	2.57
AUGUAUAU	2.9E-62	9995	145	991	98	6.82
UGUAUAUU	2.2E-61	9995	129	965	91	7.31
UUUUAA	9.2E-61	9995	1091	1000	290	2.66
AUUGUA	1.0E-60	9995	438	1020	174	3.89
GUAUAUAU	8.2E-60	9995	119	991	87	7.37
UGUAUAUAU	1.1E-59	9995	105	887	79	8.48
UUUGU	1.2E-59	9995	2181	1024	449	2.01
UGUAAAUU	3.6E-59	9995	130	908	88	7.45
UGUAAAUAU	1.3E-58	9995	103	905	78	8.36
UUUAAA	1.4E-58	9995	1013	1006	275	2.70
UAAAUAA	1.4E-58	9995	254	999	127	5.00
UUUUUA	3.8E-58	9995	1062	999	281	2.65
UGUACA	5.4E-58	9995	513	1038	188	3.53
AUAUAUU	5.5E-58	9995	254	991	126	5.00
AAUUU	6.8E-58	9995	1913	1006	405	2.10
UAUAUAUA	4.6E-57	9995	124	893	84	7.58
AUUUA	5.7E-57	9995	1623	995	361	2.23
UAUUUA	1.9E-56	9995	609	972	198	3.34
AUGUAAAU	2.5E-56	9995	149	1001	95	6.37
UAUAC	3.9E-56	9995	757	1013	229	2.98
AAUAAA	3.9E-56	9995	802	984	233	2.95
UAUUA	9.5E-56	9995	1108	986	282	2.58
CUGUAUAU	2.2E-55	9995	98	905	74	8.34
AUAAAU	2.4E-55	9995	570	999	192	3.37

Below DRIMust presents the most significant motifs computed over these k-mers:

Motif 1:
P-value ≤ 4.9E-324 There are B=702 occurrences of the motif, out of which b=422 occur at the top n=789 sequences.
Download logo in format	Clicking this button opens a pop-up window presenting the occurrences of the motif in the input sequences, aligned to each other. The occurrences are colored by the logo color scheme and the flanking positions are colored in black. Each occurrence is identified by the title of the sequence in which it occurs, the index of the sequence in the query list, the starting position of the occurrence in the sequence and the strand (in double-strand search mode only). Clicking this button opens a pop-up window showing a schematic presentation of the distribution of the motif occurrences in the query sequences. Each line represents an input sequence (following the original order), where a bold line is a sequence containing the motif. The occurrences are represented by colored blocks (fuchsia for the occurrences at the plus strand and blue for the occurrences at the minus strand). Placing the cursor on a motif occurrence reveals the title of the sequence in which it occurs, the starting position of the occurrence in the sequence and the strand (in double-strand search mode only). Download motif occurrences as text file

If you use DRIMust please cite:

Leibovich L, Paz I, Yakhini Z, Mandel-Gutfreund Y. (2013) DRIMust: a web server for Discovering Rank Imbalanced Motifs Using Suffix Trees. Nucleic Acids Res., 2013. [PDF]

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